Synthesis of epothilones, intermediates thereto, analogues...

Details Synthesis of epothilones, intermediates thereto, analogues... Synthesis of epothilones, intermediates thereto, analogues...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/335 (2006.01) A61K 31/337 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/475 (2006.01) A61K 31/585 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01) C07C 69/007 (2006.01) C07D 209/08 (2006.01) C07D 211/82 (2006.01) C07D 213/28 (2006.01) C07D 233/54 (2006.01) C07D 233/56 (2006.01) C07D 233/64 (2006.01) C07D 263/32 (2006.01) C07D 277/24 (2006.01) C07D 303/14 (2006.01) C07D 307/36

Patent

CA 2273083

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

L'invention concerne des procédés convergents pour la préparation d'épothilone A et B, de désoxyépothilones A et B et des analogues de celles-ci. Elle porte aussi sur des analogues relatifs à l'épothilone A et B et à des intermédiaires utiles pour leur préparation. Elle se rapporte encore à des nouvelles compositions à base desdites épothilones et à des procédés de traitement du cancer et de cancer à phénotype multirésistant.

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