C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/335 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) C07C 59/185 (2006.01) C07C 59/76 (2006.01) C07C 69/66 (2006.01) C07C 69/738 (2006.01) C07D 209/12 (2006.01) C07D 233/54 (2006.01) C07D 263/34 (2006.01) C07D 277/08 (2006.01) C07D 277/22 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 277/30 (2006.01) C07D 313/00 (2006.01) C07D 493/04 (2006.01) C07F 7/02 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2322157
The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.
La présente invention concerne des méthodes convergentes de préparation d'épothilones A et B, de désoxyépothilones A et B et de leurs analogues, s'utilisant dans le traitement du cancer et d'un cancer ayant développé un phénotype de résistance multiple aux anti-cancéreux. L'invention concerne également des intermédiaires s'utilisant dans la préparation de ces épothilones.
Balog Aaron
Bertinato Peter
Bertino Joseph R.
Chou Ting-Chao
Danishefsky Samuel J.
Robic
Sloan-Kettering Institute For Cancer Research
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