Synthesis of estetrol via estrone derived steroids

Details Synthesis of estetrol via estrone derived steroids Synthesis of estetrol via estrone derived steroids

C - Chemistry, Metallurgy

07

J

C07J 21/00 (2006.01) C07J 1/00 (2006.01)

Patent

CA 2505190

A process is provided for the making of estetrol starting from a 3-A-oxy-estra 1,3,5(10),15-tetraen-17-one, wherein A is an C1-C5 alkyl group, preferably a methyl group, or a C7 - C12 benzylic group, preferably a benzyl group. This process is particularly suitable to industry.

Cette invention concerne une méthode d'obtention d'estérol à partir d'un 3-A-oxy-estra 1,3,5(10),15-tétraène-17-one, dans lequel A est un groupe alkyle en C¿1?-C¿5?, de préférence un groupe méthyle, ou un groupe benzylique en C¿7? - C¿12?, de préférence un groupe benzyle. Ce procédé est tout particulièrement destiné à l'industrie.

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