Synthesis of glatiramer acetate

Details Synthesis of glatiramer acetate Synthesis of glatiramer acetate

C - Chemistry, Metallurgy

07

K

C07K 1/06 (2006.01) C07K 1/00 (2006.01) C08G 69/10 (2006.01) C08G 69/48 (2006.01)

Patent

CA 2733500

A process of making a polylpeptide or a pharmaceutically acceptable salt thereof comprises reacting a L-lysine protected polypeptide, which comprises L-alanine, L- tyrosine, L-glutamate, and L-lysine that is protected with a protecting group, with a tetraalkylammonium hydroxide in water to remove the protecting group.

Linvention concerne un procédé de fabrication dun polypeptide ou dun sel pharmaceutiquement acceptable de celui-ci, qui comprend la réaction dun polypeptide de L-lysine protégée, lequel comprend la L-alanine, la L-tyrosine, le L-glutamate et la L-lysine qui est protégée avec un groupe protecteur, avec de lhydroxyde de tétraalkylammonium dans de leau pour éliminer le groupe protecteur.

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