C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/10 (2006.01) A61K 31/685 (2006.01) A61P 35/00 (2006.01) C07D 309/10 (2006.01) C07H 3/02 (2006.01)
Patent
CA 2610792
The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.
L'invention concerne les synthèses et les propriétés antitumorales in vitro des composés phospholipidiques contenant des carbamates, des dicarbamates et uréido qui présentent une liaison éther en position C-1 d'un squelette glycérol, une fraction carbamate, dicarbamate ou uréido en position C-2 du squelette glycérol, et une fraction phosphocholine, phosphonocholine ou glycoside en position C-3 du squelette glycérol. L'invention concerne également la synthèse et l'activité antiproliférante des lipides éthers avec une fraction naphtol en position C-1. Ces composés se sont révélés comme de puissants inhibiteurs de la croissance cellulaire cancéreuse. Ces composés sont utilisés pour l'élimination des cellules cancéreuses et le traitement du cancer.
Bittman Robert
Byun Hoe-Sup
Gilbert Arthur
Battison Williams Dupuis
Bittman Robert
Byun Hoe-Sup
Gilbert Arthur
The University Of Manitoba
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