Synthesis of glycoconjugates of the lewis y epitope and uses...

Details Synthesis of glycoconjugates of the lewis y epitope and uses... Synthesis of glycoconjugates of the lewis y epitope and uses...

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07H 3/06 (2006.01) C07H 5/06 (2006.01) C07H 13/04 (2006.01) C07H 15/10 (2006.01) C07H 15/203 (2006.01) C07K 9/00 (2006.01) C07K 14/435 (2006.01) C07K 14/765 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2227592

The present invention provides a method of synthesizing an allyl pentasaccharide having structure (I) as well as related oligosaccharide ceramides and other glycoconjugates useful as vaccines for inducing antibodies to epithelial cancer cells in an adjuvant therapy therefor, and in a method for preventing recurrence of epithelial cancer.

L'invention concerne un procédé de synthèse d'un pentasaccharide allylique de structure (I), ainsi que de céramides oligosaccharidiques apparentés et d'autres glycoconjugués pouvant servir de vaccins destinés à induire la production d'anticorps contre les cellules d'un cancer épithélial dans le cadre du traitement adjuvant de ce dernier, ainsi qu'une méthode pour empêcher la réapparition du cancer épithélial.

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