Synthesis of high molecular weight non-peptidic polymer...

Details Synthesis of high molecular weight non-peptidic polymer... Synthesis of high molecular weight non-peptidic polymer...

C - Chemistry, Metallurgy

08

G

C08G 65/329 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2431977

High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the reaction steps can be accomplished on the more readily purified small molecule to avoid laborious purification of the high molecular weight derivatives.

L'invention concerne des dérivés de poly(éthylèneglycol) activé de poids moléculaire élevé et de polymères analogues préparés avec une grande pureté en conjuguant une grande molécule PEG et une petite molécule PEG. On peut soumettre la petite molécule la plus facilement purifiée à la plupart des étapes de réaction pour éviter la purification laborieuse des dérivés à poids moléculaire élevé.

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