Synthesis of histamine dihydrochloride

Details Synthesis of histamine dihydrochloride Synthesis of histamine dihydrochloride

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) C07D 233/64 (2006.01)

Patent

CA 2356871

The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L- histidine HCI monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.

Dans la présente invention, on divulgue la préparation de dichlorhydrate d'histamine de qualité pharmaceutique au moyen d'une méthode de synthèse non enzymatique en deux étapes. On y décrit la synthèse du dichlorhydrate d'histamine par décarboxylation non enzymatique d'histidine et de la conversion progressive du produit décarboxylé sous forme de dichlorhydrate. L'invention a pour objet un produit final de chlorhydrate d'histamine contenant moins de chacun des constituants suivants, soit moins de 0,8 % de monohydrate de chlorhydrate de L-histidine, moins de 0,1 % d'impuretés chromatiques individuelles et moins de 2 % d'impuretés au total. Ce produit est acceptable pour une utilisation pharmaceutique.

Affiliated with

Also associated with

Rating

Synthesis of histamine dihydrochloride does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of histamine dihydrochloride, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of histamine dihydrochloride will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1354943