Synthesis of iodixanol in methanol

Details Synthesis of iodixanol in methanol Synthesis of iodixanol in methanol

C - Chemistry, Metallurgy

07

C

C07C 231/12 (2006.01) C07C 237/46 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2710618

This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N'- bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- isophthalamide with methanol as solvent.

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