Synthesis of lipopolysaccharide-protein conjugate vaccines...

A - Human Necessities – 61 – K

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A61K 39/385 (2006.01) A61K 39/02 (2006.01) A61K 39/095 (2006.01) A61K 39/102 (2006.01) A61K 39/116 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2477068

This invention relates to lipopolysaccharide-protein conjugate vaccines with appropriate presentation of conserved inner core oligosaccharide epitopes having improved immunogenic properties. These are based upon antigenic, detoxified bacterial lipopolysaccharides which optimally present an inner core oligosaccharide epitope following removal of at least a glycosidic phosphate of the lipid A region. These partially or completely dephosphorylated antigenic, detoxified bacterial lipopolysaccharides are linkable to an immunologically acceptable carrier and can be used in polyvalent or multivalent vaccines.

L'invention porte sur des vaccins conjugués de protéine-lipopolysaccharide avec une présentation appropriée d'épitopes d'oligosaccharide à noyau interne conservés présentant de meilleures propriétés immunogéniques. Ils sont à base de lipopolysaccharides bactériens détoxiqués antigéniques qui présentent de manière optimale un épitope d'oligosaccharide à noyau interne après retrait d'au moins un phosphate glycosidique de la région lipidique A. Ces lipopolysaccharides bactériens détoxiqués antigéniques partiellement ou entièrement déphosphorylés peuvent être liés à un porteur immunologiquement acceptable et peuvent être utilisés dans des vaccins polyvalents ou multivalents.

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