C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/16 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2484526
The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as .alpha.-L-oxy-LNA, amino-LNA, .alpha.-L-amino-LNA, thio-LNA, .alpha.-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues. (Formula I)
L'invention concerne une nouvelle stratégie permettant la synthèse de dérivés de LNA (Locked Nucleic Acid) tels que .alpha.-L-oxy-LNA, amino-LNA, .alpha.-L-amino-LNA, thio-LNA, .alpha.-L-thio-LNA, séléno-LNA et méthylène LNA. Cette stratégie permet la mise en oeuvre de réactions à haut rendement, modulables, comprenant l'utilisation d'intermédiaires qui permettent également d'obtenir d'autres analogues de LNA tels que les oxy-LNA. L'invention concerne également les composés représentés par la formule X, qui sont des intermédiaires importants capables de réagir avec divers nucléophiles et permettant ainsi d'obtenir une large variété d'analogues de LNA. (formule X)
Christensen Signe M.
Koch Troels
Pedersen Daniel Sejer
Rosenbohm Christoph
Sorensen Mads Detlef
Exiqon A/s
Gowling Lafleur Henderson Llp
Santaris Pharma A/s
LandOfFree
Synthesis of locked nucleic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthesis of locked nucleic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of locked nucleic acid derivatives will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1835949