Synthesis of novel neamine derivatives and use thereof as...

C - Chemistry – Metallurgy – 07 – H

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C07H 15/224 (2006.01) A61K 31/4704 (2006.01) A61K 31/7028 (2006.01) A61K 31/7036 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2711725

The invention relates to compounds of the formula (I) in which: R1 = OH or NH2; OR2, OR3, OR4 and OR5 form alcohol, ether, ester, carbonate, carbamate, sulphonate or sulphamate functions; and if R5 = H, if R2 =R3=R4, then R2, R3 and R4 ? H; if R2 = H, then R3 ? H and R4 ? H; if R3 = H, then R2 ? H and R4 ? H; if R4 = H, then R2 ? H and R3 ? H; if R5 ? H, if R2 = H, then R3 ? H and R4 ? H; if R3 = H, then R2 ? H and R4 ? H; if R4 = H, then R2 ? H and R3 ? H. The invention also relates to the use thereof as antibiotic agents and to a method for their synthesis.

La présente invention concerne des composés de formule (I) dans laquelle : R1 = OH ou NH2; OR2, OR3, OR4 et OR5 forment des fonctions alcool, éther, ester, carbonate, carbamate, sulfonate ou sulfamate; et si R5 = H, si R2 =R3=R4, alors R2, R3 et R4:.noteq. H;si R2 =H,alors R3:.noteq. H et R4:.noteq. H;si R3=H,alors R2:.noteq. H et R4:.noteq. H;si R4=H,alors R2:.noteq. H et R3:.noteq. H;si R5:.noteq. R5 .noteq. H R2 = H, alors R3 :.noteq. H et R4 :.noteq. H; si R3 = H, alors R2 H et R4 :.noteq. H; si R4 = H, alors R2 :.noteq. H et R3 :.noteq. H, leur utilisation en tant qu'agents antibiotiques et leur procédé de synthèse.

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