Synthesis of nucleosides and polynucleotides

Details Synthesis of nucleosides and polynucleotides Synthesis of nucleosides and polynucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7052 (2006.01) A61K 31/7088 (2006.01) A61P 31/12 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07K 14/08 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2275964

Novel nucleosides, process for chemical synthesis of nucleosides and incorporation of the nucleosides into polynucleotides are disclosed. Also described are polynucleotides, such as antisense, TFO and nucleic acid catalysts with one or more modifications, such as 2'-O-amino, L-nucleotides and the others.

L'invention concerne de nouveaux nucléosides, un procédé servant à effectuer la synthèse chimique de nucléosides et l'incorporation des nucléosides dans des polynucléotides. Elle concerne également des polynucléotides, tels que des molécules d'acide nucléique non enzymatiques "antisens", des oligonucléotides formant un triplex (TFO) et des catalyseurs d'acide nucléique présentant une ou plusieurs modifications, telles que 2'-O-amino, L-nucléotides et les autres.

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