Synthesis of oligonucleotides

Details Synthesis of oligonucleotides Synthesis of oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07F 9/24 (2006.01) C07F 9/547 (2006.01) C07F 9/655 (2006.01) C07H 13/04 (2006.01)

Patent

CA 2131994

2131994 9320092 PCTABS00027 A method for the synthesis of a plurality of oligonucleotides comprising the steps of (i) forming a first oligonucleotide on a first cleavable link attached to a solid support; (ii) attaching to the first oligonucleotide a cleavable linker moiety; (iii) forming a second oligonucleotide on the cleavable linker moiety; and (iv) cleaving the first cleavable link and the cleavable linker moiety to give a plurality of oligonucleotides; wherein the cleavable linker moiety is of formula (1), in which A1, A2 and E are as defined herein, and novel compounds which may be used in the operation of the method.

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