Synthesis of oligonucleotides

Details Synthesis of oligonucleotides Synthesis of oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07F 9/24 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2093356

2093356 9206103 PCTABS00011 A method for the synthesis of a plurality of oligonucleotides in which an oligonucleotide is formed by sequential reactions of precursors of individual nucleotides on a support, comprising the steps of (a) forming a first oligonucleotide; (b) attaching to said first oligonucleotide a cleavable linker moiety; (c) forming a second oligonucleotide on the cleavable linker moiety; and (d) optionally cleaving the linker moiety to give the desired oligonucleotides. The invention also concerns nucleoside and non-nucleoside reagents suitable for incorporating cleavable linker moieties during automated oligonucleotide synthesis, cleavage of which produces oligonucleotides having a hydroxy or phosphate group at the 3' and 5' positions, and solid supports suitable for use in automated oligonucleotide synthesisers.

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