Synthesis of optically active phenylalanine analogs through...

Details Synthesis of optically active phenylalanine analogs through... Synthesis of optically active phenylalanine analogs through...

C - Chemistry, Metallurgy

12

P

C12P 13/04 (2006.01) C12P 13/22 (2006.01)

Patent

CA 2283376

A biocatalytic process to produce optically active phenylalanine analogs from arylacrylic acids is disclosed in which Rhodotorula graminis yeast containing phenylalanine ammonia-lyase introduces a molecule of ammonia stereoselectively onto the double bond of a 3-substituted acrylic acid. The substituent at the 3-position of the 3-substituted acrylic acid includes, for example, aromatic rings such as substituted phenyl groups, five member aromatic heterocyclics, and six member aromatic heterocyclics.

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