Synthesis of peloruside a and analogs thereof for use as...

C - Chemistry – Metallurgy – 07 – F

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C07F 7/08 (2006.01) A61K 31/357 (2006.01) A61P 35/00 (2006.01) C07D 309/10 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2516393

The present invention provides (+)- Peloruside A and analogs thereof having microtubule-stabilizing activity, and a process for synthesizing these compounds. Also provided are intermediates and a process for synthesizing thereof. These compounds exhibit antiproliferative activity and are useful for treating cancer.

La présente invention concerne le peloruside A et des analogues de celui-ci présentant une activité stabilisatrice des microtubules, ainsi qu'un procédé permettant de synthétiser ces composés. L'invention concerne également des produits intermédiaires ainsi qu'un procédé permettant de les synthétiser. Ces composés présentent une activité antiproliférative et ils sont utilisés pour traiter le cancer.

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