Synthesis of pharmaceutical useful pyridine derivatives

Details Synthesis of pharmaceutical useful pyridine derivatives Synthesis of pharmaceutical useful pyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/78 (2006.01) C07D 213/61 (2006.01) C07D 213/68 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2225863

A process is provided for the preparation of compounds of formula I, Image useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1=H or CH3, R2=H or CH3, R3=Alkoxy (1-4C), OCH2CF3, Cyano, Hydrogen, Halogen, Acetoxy or Aryloxy, any electron withdrawing group or salts (organic or inorganic) of electron donating groups, R=Alkoxy, Hydroxy, Halogen, Activated ester, Tosylate, Mesylate, Thiol or Xanthyl, wherein the process for the preparation of compound of formula I employs a free radical reaction to functionalize the 2-position.

Divulgation d'un procédé de préparation de composés de formule I, Image , utiles pour la préparation de composés comme l'Oméprazole, le Lansoprazole et le Pantoprazole, dans laquelle R1 est un H ou un CH3, R2 est un H ou un CH3, R3 est un alcoxy en C1-4, OCH2CF3, un groupement cyano, un hydrogène, un halogène, un acétoxy ou un aryloxy, tout groupe arrachant des électrons ou un sel (organique ou inorganique) de groupes donneurs d'électrons, R est un alcoxy, un hydroxy, un halogène, un ester activé, un tosylate, un mésylate, un thiol ou un xanthyle. Le procédé de préparation du composé de formule I fait intervenir une réaction avec un radical libre pour placer un groupement fonctionnel en position 2.

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