C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 257/02 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07D 259/00 (2006.01) C07F 5/00 (2006.01) C07F 9/547 (2006.01) C07F 9/6515 (2006.01) C07F 9/6524 (2006.01)
Patent
CA 2125773
2125773 9312097 PCTABS00022 The pH controlled selectivity of the sulfomethylation reaction is used to prepare a series of di-, tri-, tetra- and hexaazacyclomacrocycles with specified patterns of pendent side-chain chelating groups. The prepared mono and diacetic acid derivatives, together with monomethylenephosphonate and monomethylenephosphinate derivatives of [12]aneN4, [12]aneN3 and [9]aneN3, make these types of ligands easily available by a synthetic pathway that avoids the use of protective groups. The invention thus comprises a variety of compounds, methods and uses characterized by relatively high synthetic yields of polyazamacrocyclic ligands exhibiting a wide and predictable choice of metal ion binding constants and water and lipid solubilities by reason of their substituent pendent groups.
Sherry A. Dean
Van Westrenen Jeroen
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
LandOfFree
Synthesis of polyazamacrocycles with more than one type of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthesis of polyazamacrocycles with more than one type of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of polyazamacrocycles with more than one type of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1889703