C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/47 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/277 (2006.01) A61P 25/28 (2006.01) C07C 51/00 (2006.01) C07C 62/30 (2006.01) C07C 67/00 (2006.01) C07C 69/757 (2006.01)
Patent
CA 2616028
A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.
L'invention concerne une nouvelle synthèse de scabronines, qui sont liées à une classe plus large de diterpénoïdes tricycliques fusionnés de manière angulaire conçues en tant que cyathanes. La scabronine G, son dérivé d'ester méthylique, et d'autres analogues présentent une activité neurotrophique. C'est pourquoi, ces composés sont particulièrement utiles dans le traitement de maladies neurodégénératives telles que la maladie d'Alzheimer, la malade de Parkinson, la chorée de Huntington, etc. L'invention concerne la synthèse de scabronines ainsi que d'analogues de celles-ci. Des compositions pharmaceutiques et un procédé d'utilisation des composés de l'invention sont également décrits.
Danishefsky Samuel J.
Waters Stephen P.
Robic
Sloan-Kettering Institute For Cancer Research
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