Synthesis of steroids

Details Synthesis of steroids Synthesis of steroids

C - Chemistry, Metallurgy

07

J

260/21, 260/60,

C07J 9/00 (2006.01) C07J 17/00 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 1141372

ABSTRACT OF THE DISCLOSURE The synthesis of 25-hydroxycholesterol and 1.alpha.,25- dihydroxycholesterol in which the sterol nucleus of an ester of hyodeoxycholic acid is stabilized by protection of the 3 and 6.alpha.-hydroxyl groups with alkyl groups, alkyl ether groups, preferably with the 3.beta.-methoxyethoxymethyl group or with the heterocyclic 2-tetrahydropyran group, then extending the chain from the carbon at the 24-position to a cyanide group at the 25-position and then subjecting the sterol so formed to a series of reactions by which it is transformed into 1.alpha.,25-dihydroxycholesterol or by a modified series of reactions to 25-hydroxycholesterol.

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