C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C07D 409/00 (2006.01) C07D 473/00 (2006.01) C07H 19/04 (2006.01) C07H 23/00 (2006.01)
Patent
CA 2078256
ABSTRACT OF THE DISCLOSURE An oligonucleotide analog of formula I in which one or more of the internucleoside phosphodiester groups are replaced by non- hydrolysable dialkyl sulfide, sulfoxide or sulfone linkages, such as in: Image in which R and R' are independently selected from H, DNA, RNA unsubstituted or substituted by I, nucleoside, nucleotides and analogs thereof; B is a base having a heterocyclic ring, X is independently O, CH2 or S; Y is independently H, OH or O-alkyl; Y' is H or O-alkyl; n is 0, 1 or 2; and m is 0 or an integer. These compounds are useful for binding selectively to complementary DNA or RNA strands (particularly mRNA strands) for use in regulating gene expression and as biological probes.
Just George
Kawai Stephen H.
Bereskin & Parr
University Mcgill
LandOfFree
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