Synthesis of the sulfonylpyrimidine derivatives with...

Details Synthesis of the sulfonylpyrimidine derivatives with... Synthesis of the sulfonylpyrimidine derivatives with...

C - Chemistry, Metallurgy

07

D

C07D 239/46 (2006.01) C07D 239/54 (2006.01) C07D 239/553 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 493/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2237267

This invention relates to the processes for the preparation of unknown N-1 sulfonyl and N-1,NH-4 disulfonyl derivatives of pyrimidine nucleo bases, general formulae I, II, III, IV, V and VI, and their biological activity. (see fig. I) (see fig. II) (see fig. III) (see fig. IV) (see fig. V) (see fig. VI) This type of compounds exhibits strong anticancer activity in vitro on different tumor cell lines whereas cytostatic behavior on normal human fibroblasts is much less pronounced.

La présente invention porte sur des méthodes de préparation de dérivés N-1-sulfonylés et N-1,NH-4-disulfonylés de bases nucléiques de pyrimidine de formules générales I, II, III, IV, V et VI, ainsi que sur leur activité biologique (voir fig. I) (voir fig. II) (voir fig. III) (voir fig. IV) (voir fig. V) (voir fig. VI). Ce type de composé exerce une forte activité anticancer in vitro sur différentes lignées de cellules tumorales, alors que le comportement cytostatique vis-à-vis des fibroblastes humains normaux est beaucoup moins prononcé.

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