Synthesis of tumor antigenic determinant

Details Synthesis of tumor antigenic determinant Synthesis of tumor antigenic determinant

C - Chemistry, Metallurgy

07

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167/129, 260/230

C07H 5/04 (2006.01) A61K 39/00 (2006.01) C07H 3/06 (2006.01) C07H 15/04 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)

Patent

CA 1203532

"SYNTHESIS OF TUMOR ARTIGENIC DETERMINANT" ABSTRACT OF THE DISCLOSURE Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-0-(.beta.-D-galactopyranosyl)-.alpha.-D- galactopyranoside containing an .alpha.-0-glycosidically linked bridging arm O-(CH2)n COR . The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artificial T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.

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