Synthesis routes to...

Details Synthesis routes to... Synthesis routes to...

C - Chemistry, Metallurgy

07

D

C07D 307/33 (2006.01) C07C 235/02 (2006.01)

Patent

CA 2731262

The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl- octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.

Cette invention concerne un procédé de préparation de composés qui sont dimportants synthons des voies de synthèse convergentes des amides 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyle ou leurs sels pharmaceutiquement acceptables, par exemple le composé Aliskiren, et un procédé de préparation des amides doctanoyle, comprenant la réaction desdits synthons.

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