C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 31/7125 (2006.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2671883
The invention provides novel oligonucleotide-based compounds that individually provide distinct immune response profiles through their interactions as agonists with TLR9. The TLR9 agonists according to the invention are characterized by specific and unique chemical modifications, which provide their distinctive immune response activation profiles.
L'invention concerne de nouveaux composés à base d'oligonucléotides qui fournissent individuellement des profils de réponse immune distincts par leurs interactions en tant qu'agonistes avec le TLR9. Les agonistes du TLR9 proposés par la présente invention sont caractérisés par des modifications chimiques spécifiques et uniques qui leur donnent leurs profils d'activation de réponse immune distinctifs.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar R.
Reddy Mallikarjuna
Wang Daqing
Benoit & Cote Associes Inc.
Idera Pharmaceuticals Inc.
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