C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/56 (2006.01) A61K 38/47 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 9/26 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2099503
The present invention relates generally to .alpha.-L--iduronidase and to genetic sequences encoding same. More particularly, the present invention provides an is-olated nucleic acid molecule comprising a sequence of nucleotides which encodes or are complementary to a sequence which encodes a mammalian .alpha.-L-iduronidase or fragment or derivative thereof and to the recombinant enzyme encoded thereby. These molecules are useful in the investigation, diagnosis and treatment of subjects suspected of or suffering from .alpha.-L-iduronidase deficiency.
Anson Donald Stewart
Clements Peter Roy
Hopwood John Joseph
Morris Charles Phillip
Nelson Paul Victor
Kirby Eades Gale Baker
Women's And Children's Hospital
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