Synthetic analogues of phosphatidyl-myo-inositol mannosides...

Details Synthetic analogues of phosphatidyl-myo-inositol mannosides... Synthetic analogues of phosphatidyl-myo-inositol mannosides...

C - Chemistry, Metallurgy

07

H

C07H 15/207 (2006.01) A61K 31/7034 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2724767

The present invention relates to novel synthetic analogues of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.

La présente invention se rapporte à de nouveaux analogues synthétiques des phosphatidyl-myo-inositol mannosides (ci-après PIM) formule générale (I) : ou un de leurs sels pharmaceutiquement acceptables, leur procédé de préparation et leur utilisation dans la prévention ou le traitement d'une maladie associée à la surexpression de cytokines ou de chimiokines, notamment du TNF et/ou de l'IL-12. L'invention concerne également une composition pharmaceutique comprenant au moins un dérivé synthétique de PIM.

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