Synthetic and standardized prion infectuous material, and...

Details Synthetic and standardized prion infectuous material, and... Synthetic and standardized prion infectuous material, and...

G - Physics

01

N

G01N 33/68 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2607586

The invention relates to a novel synthetic, standardized, soluble, reproducible and easy to handle prion infectious material that consists of a cultured cellular lysate or supernatant fluid from stable transgenic cells expressing a prion protein PrP and supporting the replication of the pathogenic form PrPsc of said PrP.

L' invention concerne un nouveau matériel infectieux de type prion, synthétique, standardisé, soluble, reproductible et facile à manipuler, qui consiste en un lysat cellulaire ou surnageant de culture provenant de cellules transgéniques stables exprimant une protéine prion PrP et supportant la réplication de la forme pathogène, PrPsc, de ladite PrP.

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