Synthetic antibody phage libraries

Details Synthetic antibody phage libraries Synthetic antibody phage libraries

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 1/22 (2006.01) C07K 16/24 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C40B 30/04 (2006.01) C40B 40/02 (2006.01) C40B 40/10 (2006.01) C40B 50/00 (2006.01) C40B 50/06 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2488441

The invention provides comprising variant amino acids in CDRs of antibody variable domains. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags, and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.

L'invention porte sur des acides aminés de variants dans des CDR de domaines variables d'anticorps. Ces polypeptides forment une source d'une grande diversité de séquences pouvant être utilisée comme source d'identification de nouveaux polypeptides se liant aux antigènes. L'invention porte également sur des polypeptides tels que des polypeptides de fusion se liant aux polypeptides hétérologues tels qu'au moins une partie des phages ou des protéines de coques virales, des étiquettes et des lieurs. L'invention porte sur des bibliothèques comprenant une pluralité de ces polypeptides, ainsi que sur des procédés et des compositions permettant de générer et d'utiliser ces polypeptides et ces bibliothèques.

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