A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/04 (2006.01) C07K 14/35 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2703668
The current invention relates to the diagnosis and treatment of diseases resulting from infections by Mycobacterium avium subsp. paratuberculosis. In particular the invention relates to the use of an antigen selected among (a) a synthetic peptide 5P having the following formula: DPhe-NMeVa1-Ile-Phe-Ala-OMe (SEQ ID NO: 1); (b) a lipopeptide L5P consisting of the synthetic peptide a) wherein the N-terminal phenylalanine residue is N- acylated with an eicosanoic acid acyl chain; (c) a variant of peptide a) or lipopeptide b) able to react with anti- Mycobacterium paratuberculosis antibodies; for in vitro detection or quantification of specific anti-Mycobacterium paratuberculosis antibodies in a biological sample.
La présente invention concerne le diagnostic et le traitement de maladies résultant d'infections par Mycobacterium avium subsp. paratuberculosis. L'invention concerne notamment l'utilisation d'un antigène choisi parmi (a) un peptide synthétique 5P présentant la formule suivante : DPhe-NMeVal-Ile-Phe-Ala-OMe (SEQ ID NO : 1) ; (b) un lipopeptide L5P constitué du peptide synthétique a), le résidu phénylalanine N-terminal étant N-acétylé avec une chaîne acyle de l'acide eicosanoïque ; (c) une variante du peptide a) ou du lipopeptide b) capable de réagir avec les anticorps anti-Mycobacterium paratuberculosis ; pour la détection ou la quantification in vitro d'anticorps anti-Mycobacterium paratuberculosis spécifiques dans un échantillon biologique.
Bay Sylvie
Biet Franck
Reyrat Jean-Marc
Institut National de La Recherche Agronomique
Institut National de La Sante Et de La Recherche Medicale (inser
Institut Pasteur
Robic
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