Synthetic archaeal glycolipid adjuvants

Details Synthetic archaeal glycolipid adjuvants Synthetic archaeal glycolipid adjuvants

C - Chemistry, Metallurgy

07

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C07H 15/04 (2006.01) A61K 9/127 (2006.01) A61K 39/39 (2006.01) A61K 47/24 (2006.01) A61K 47/26 (2006.01) A61K 47/28 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2647060

Archaeal lipid adjuvants are synthesized by chemically coupling various carbohydrates or anionic polar groups to the free hydroxyl(s) of archaeal lipid cores. Chemically stable lipid cores such as saturated archaeol and caldarchaeol are obtained from appropriate Archaea. Archaeosome lipid vesicles are formulated from the synthetic lipids selected to serve as antigen carriers that target antigen-presenting cells and promote an appropriate immune response to the antigen.

L'invention concerne des adjuvants lipidiques d'Archaea dont la synthèse est effectuée par couplage chimique de carbohydrates variés ou de groupes polaires anioniques avec le ou les hydroxyle(s) libre(s) de noyaux lipidiques d'Archaea. On obtient des noyaux lipidiques chimiquement stables, tels que des archaeols et des caldarchaeols à partir d'Archaea appropriés. Les vésicules lipidiques d'archaeosomes sont formulées à partir des lipides synthétiques sélectionnés pour servir de vecteurs d'antigènes qui ciblent des cellules présentant des antigènes et favorisent une réponse immunitaire appropriée aux antigènes.

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