Synthetic aryl polyamines as excitatory amino acid...

Details Synthetic aryl polyamines as excitatory amino acid... Synthetic aryl polyamines as excitatory amino acid...

C - Chemistry, Metallurgy

07

D

C07D 213/56 (2006.01) A61K 31/165 (2006.01) A61K 31/295 (2006.01) A61K 31/405 (2006.01) A61K 31/435 (2006.01) C07C 233/40 (2006.01) C07C 235/34 (2006.01) C07D 209/18 (2006.01) C07D 209/20 (2006.01) C07D 215/14 (2006.01) C07D 241/42 (2006.01) C07D 403/12 (2006.01) C07F 17/02 (2006.01)

Patent

CA 2114798

2114798 9304036 PCTABS00020 Compounds having the formula R-(CH2)m-CO-R' wherein R is a 5 to 7 member carbocyclic system or an 8 to 11 member carbobicyclic system or any such system substituted with one or more of F, Cl, Br, OH, C1 to C4 alkyl, C1 to C4 alkoxy, CF3, phenyl, amino, C1 to C4 alkylamino and di(C1 to C4 alkyl)amino; m is 0 or 1; R' is -[NH(CH2)n]xNH2; each n is independently 2 to 5; and x is 1 to 6, and their pharmaceutically acceptable acid addition salts are potent excitatory amino acid neurotransmitter antagonists. These compounds are useful as mammalian psychotherapeutants, as the active ingredient in pharmaceutical compositions for treating conditions in mammals which are mediated by excitatory amino acid neurotransmitters and in the control of invertebrate pests.

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