C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 38/18 (2006.01) A61K 47/42 (2006.01) A61L 24/10 (2006.01) A61L 27/22 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/475 (2006.01) C12N 1/21 (2006.01) A61L 25/00 (1990.01)
Patent
CA 2098303
This invention pertains to a synthetic adhesive composition for use in aqueous environments. The composition comprises polypeptide chains having an .alpha.-helical structure in aqueous environments and capable of cohesive and adhesive interactions. The polypeptide chains comprise polar and apolar amino acids, the apolar and polar amino acids being arranged to define apolar and polar vertical spiraling stripes on the helix surface. The apolar strips allow the polypeptide chains to aggregate into superhelical structures and the polar stripes allow interchain crosslinking within and between the superhelical structures.
L'invention concerne une composition adhésive synthétique utilisée dans des environnements aqueux. La composition comprend des chaînes polypeptides ayant une structure alpha-hélicoïdale dans des environnements aqueux et capables d'interactions cohésives et adhésives. Les chaînes de polypeptides comprennent des acides aminés polaires et apolaires agencés pour définir des bandes spiralées verticales polaires sur la surface hélicoïdale. Les bandes apolaires permettent aux chaînes polypeptides de s'aggréger pour former des structures superhélicoïdales et les bandes polaires permettent la réticulation interchaîne dans et entre les structures superhélicoïdales.
Cohen Charles M.
Keck Peter C.
Pang Roy H. L.
Curis Inc.
Riches Mckenzie & Herbert Llp
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