Synthetic catalytic oligonucleotide structures

Details Synthetic catalytic oligonucleotide structures Synthetic catalytic oligonucleotide structures

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2071446

A b s t r a c t A synthetic catalytic oligonucleotide structure and nucleotides having the general structural formula (I) contains: Image (I) in which B represents a nucleoside base which is in particular selected from the group comprising adenin-9- yl (A), cytosin-1-yl (C), guanin-9-yl (G), uracil-1-yl (U), uracil-5-yl (?), hypoxanthin-9-yl (I), thymin-1-yl (T) and 2-aminoadenin-9-yl, V in each nucleotide is independently an O or a CH2 group, X and W can in each nucleotide be the same or different and are independently of each other O, S, NH2, alkyl or alkoxy groups with 1 to 10, preferably with 1 to 4 carbon atoms, R is hydrogen or a straight-chained or branched alkyl, alkenyl or alkinyl group with 1 to 10 carbon atoms which is substituted, if desired, with halogen, cyano, isocyano, nitro, amino, carboxyl, hydroxyl or/and mercapto groups, and in which in at least one of the nucleotides the residue R in formula (I) is different from hydrogen and is suitable for the cleavage of a nucleic acid target sequence.

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