Synthetic chemokines, methods of manufacture, and uses

Details Synthetic chemokines, methods of manufacture, and uses Synthetic chemokines, methods of manufacture, and uses

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01)

Patent

CA 2561171

The invention relates to synthetic chemokines, methods of manufacture and uses thereof. The synthetic chemokines of the invention include one or more amino acid deletions at the C-terminus relative to the corresponding wild type chemokine, which also can include one or more covalently attached polymers, as well one or more additional amino acid changes or chemical modifications. The invention also provides synthetic chemokines in a substantially purified oligomeric form, such as, in a monomer or dimer form. Further provided are methods for synthesizing the synthetic chemokines of the invention, pharmaceutical formulations and kits thereof, and their use as research tools and medicaments.

L'invention concerne des chimiokines de synthèse, leurs procédés de production, et leurs utilisations. Parmi les chimiokines de synthèse selon l'invention figurent des chimiokines qui ont subi une ou plusieurs délétions d'aminoacides au niveau du C-terminal par rapport à la chimiokine de type sauvage correspondante, qui comportent un ou plusieurs polymères liés par covalence, et qui ont subi un ou plusieurs changements d'aminoacides supplémentaires ou modifications chimiques. Cette invention se rapporte en outre à des chimiokines de synthèse sous forme oligomère sensiblement purifiée, par exemple sous forme monomère ou dimère. La présente invention concerne par ailleurs des procédés pour synthétiser lesdites chimiokines de synthèse, des formulations pharmaceutiques et des nécessaires correspondants, ainsi que l'utilisation de ces chimiokines de synthèse en tant qu'outils de recherche et médicaments.

Affiliated with

Also associated with

Rating

Synthetic chemokines, methods of manufacture, and uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic chemokines, methods of manufacture, and uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic chemokines, methods of manufacture, and uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1693508