Synthetic compounds and compositions with enhanced cell binding

Details Synthetic compounds and compositions with enhanced cell binding Synthetic compounds and compositions with enhanced cell binding

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61L 27/00 (2006.01) C07K 14/78 (2006.01) C07K 17/00 (2006.01) C12N 5/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2124583

2124583 9311781 PCTABS00022 Compositions of the invention include composites comprising a biomaterial carrying compounds with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docketing of collagen binding species (such as cell surface receptors for collagen and fibronectin). Hydrogel matrices as the biomaterial promote cell attachment to the matrix and cell migration into the matrix.

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