C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 7/02 (2006.01) A61K 31/70 (2006.01) A61K 31/702 (2006.01) A61K 31/715 (2006.01) A61K 31/726 (2006.01) A61P 1/04 (2006.01) A61P 11/00 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) A61P 35/04 (2006.01) A61P 37/06 (2006.01) C07H 1/00 (2006.01) C07H 13/04 (2006.01) C07H 15/12 (2006.01) C07H 17/04 (2006.01) C08B 37/00 (2006.01) C12P 19/18 (2006.01) C12P 19/26 (2006.01)
Patent
CA 2302470
The present invention is directed to novel compositions and their use in the treatment of inflammatory responses. Specifically, the invention is directed to novel synthetic oligosaccharide constructs and their use to block lymphocyte binding to correspondent oligosaccharides on the endothelial surface, and thus reduce or otherwise ameliorate an undesired inflammatory response. The invention is further directed to the use of such constructs in other disease states characterized by selectin binding, such as bacterial infections and metastatic cancers.
La présente invention concerne de nouvelles compositions et leur utilisation dans le traitement de réactions inflammatoires. Plus spécifiquement, l'invention concerne de nouveaux produits de recombinaison d'oligosaccharides synthétiques et leur utilisation pour bloquer une liaison lymphocytaire à des oligosaccharides correspondants sur la surface endothéliale, ce qui permet de réduire ou d'améliorer une réaction inflammatoire non voulue. L'invention concerne également l'utilisation de ces produits de recombinaison dans d'autres affections caractérisées par une liaison de sélectine, telles que des infections bactériennes et des cancers métastatiques.
Renkonen Ossi
Renkonen Risto
Glycim Oy
Robic
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