C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2453301
The invention relates to oligonucleotide derivatives which are at least partially double stranded and which comprise a 2'5' linked oligonucleotide radical on at last one 3'- end. The invention also relates to the use thereof for targeted inhibition of gene expression.
L'invention concerne des dérivés d'oligonucléotides qui se présentent au moins partiellement sous la forme d'un double brin et qui comportent au niveau d'au moins une extrémité 3' un groupe oligonucléotide lié en 2'5'. L'invention concerne également l'utilisation de ces dérivés pour inhiber de façon ciblée l'expression génique.
Gunkel Niki
Huber Jochen
Neumann Sandra
Uhlmann Eugen
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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