Synthetic elastomeric insoluble cross-linked polypentapeptide

Details Synthetic elastomeric insoluble cross-linked polypentapeptide Synthetic elastomeric insoluble cross-linked polypentapeptide

C - Chemistry, Metallurgy

08

G

530/7.06

C08G 69/10 (2006.01) A61F 2/06 (2006.01) A61L 27/22 (2006.01)

Patent

CA 1103238

ABSTRACT OF THE DISCLOSURE An insoluble cross-linked polypentapeptide is totally synthesized by preparing two modified linear polypentapep- tides patterned on the polypentapeptide from the pentapeptide (Val1-Pro2-Gly3-Val4-Gly5) one of the repeating peptide sequences contained in tropoelastin, the precursor protein of the core of the elastic fiber of the vascular wall, and by cross-linking the modified polypentapeptides. One of the intermediate polypentapeptides is modified by replacing a portion of at least one of the amino acid residues with the residue of an amino acid having more than one amino function and the other is modified by replacing a portion of at least one of the amino acid residues with the residue of an amino acid having more than one carboxyl function, to provide free amino groups on the one intermediate and free carboxyl groups on the other for interreaction in the presence of a suitable cross-linking agent. The resulting cross-linked insoluble polypentapep- tide is elastomeric in nature and capable of calcification by withdrawing calcium ions from a serum medium, thus making it useful as a calcifiable matrix for the formation of an artificial bone structure. The calcifiable material can be treated to make it useful in artificial vascular wall formation.

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