Synthetic eukaryotic promoters containing two inducible...

Details Synthetic eukaryotic promoters containing two inducible... Synthetic eukaryotic promoters containing two inducible...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2128602

Synthetic inducible eukaryotic promoters for the regulation of transcription of a gene achieve improved levels of protein expression and lower basal levels of gene expression. Such promoters contain at least two different classes of inducible elements, usually by modification of a native promoter containing one of the inducible elements by inserting the other of the inducible elements. In embodiments, additional metal responsive elements (MREs) and/or glucocorticoid responsive elements (GREs) are provided to native promoters, particularly the hMT-11A and MMTV-LTR promoters. One or more constitutive elements may be functionally disabled to provide the lower basal levels of gene expression.

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