Synthetic gagpol genes and their uses

Details Synthetic gagpol genes and their uses Synthetic gagpol genes and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/48 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2408433

The present invention relates to synthetic gag and gagpol genes optimized for high level expression via codon optimization and the uses thereof for the efficient generation of vector particles. The invention further relates to the generation of packaging cells and vaccines based on the synthetic gag and gagpol genes.

L'invention concerne des gènes gag et gagpol synthétiques optimisés pour une expression de niveau élevé via une optimisation de codon, ainsi que leurs utilisations pour la production efficace de particules de vecteur. Elle concerne aussi la production de cellules d'enrobage et de vaccins basés sur les gènes synthétiques gag et gagpol.

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