Synthetic gene control region

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/04 (2006.01) C12N 1/19 (2006.01)

Patent

CA 2611877

The present invention provides a synthetic gene control region which comprises a gene regulatory sequence comprising a binding site for a gene regulatory protein of a yeast strain, and a promoter from filamentous fungal strain located downstream of the gene regulatory sequence; wherein the promoter can be recognized by the general transcription factors and RNA polymerase of the yeast strain; wherein the gene regulatory sequence is capable of regulating transcription initiated by the filamentous fungal promoter in the yeast strain.

L'invention concerne une région de régulation d'un gène synthétique, cette région comprenant une séquence régulatrice d'un gène comprenant un site de liaison pour une protéine régulatrice d'un gène d'une souche de levure, ainsi qu'un promoteur provenant d'une souche de champignon filamenteux situé en aval de la séquence régulatrice du gène. Le promoteur peut être identifié d'après les facteurs de transcription généraux et l'ARN polymérase de la souche de levure. La séquence régulatrice du gène peut réguler la transcription initiée par le promoteur de champignon filamenteux dans la souche de levure.

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