Synthetic hcv envelope proteins and their use for vaccination

Details Synthetic hcv envelope proteins and their use for vaccination Synthetic hcv envelope proteins and their use for vaccination

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 31/713 (2006.01) A61K 38/16 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) C07K 14/18 (2006.01) C07K 16/10 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2460509

The present invention relates to the amino acid and deduced nucleic acid sequence of synthetic E2 proteins comprising a consensus sequence of the most conserved amino acids found in E2 of 77 different HCV 1b isolates worldwide. The invention further relates to a truncated version of the E2 protein lacking HVR1. Another aspect of the present invention concerns a vaccine comprising the E2 proteins.

L'invention concerne un amino-acide et la séquence d'acide nucléique déduite de protéines E2 de synthèse, comprenant une séquence consensus d'amino-acides les mieux conservés trouvés dans la protéine E2 parmi 77 isolats VHC 1b dans le monde entier. L'invention concerne également une version tronquée de la protéine E2 exempte de HVR1 (région hypervariable 1). L'invention concerne en outre un vaccin à base de protéines E2.

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