A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/130, 167/37
A61K 39/29 (2006.01) C07K 14/02 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1253069
ABSTRACT A vaccine against infection by hepatitis B virus comprising: a) an effective amount of at least one synthetic polypeptide having an amino acid residue sequence taken from left to right in the direction from amino-terminus to carboxy-terminus selected from the group consisting of: SerLeuAsnPheLeuGlyGlyThrThrValCysLeuGlyGlnAsn; ValCysLeuGlyGlnAsn; CysLeuGlyGlnAsnSerGlnSerProThrSerAsnHisSerProThrSer CysProProThrCysProGlyTyrArgTrpMetCysLeuArgArgPheIle; LeuValLeuLeuAspTyrGlnGlyMetLeuProValCysProLeu; and ThrLysProSerAspGlyAsnCysThrCysIleProIleProSer; b) an effective amount of at least one synthetic polypep- tide having an amino acid residue sequence taken from left to right and in the direction from amino-terminus to carboxy-termin- us selected from the group consisting of: PheProGlySerSerThrThrSerThrGlyProCysArgThrCys MetThrThrAlaGlnGlyThrSerMetTyrProSerCys; MetThrThrAlaGlnGlyThrSerMetTyrProSerCys; IleProGlySerThrThrThrSerThrGlyProCysLysThrCys ThrThrProAlaGlnGlyAsnSerMetPheProSerCys; ThrThrProAlaGlnGlyAsnSerMetPheProSerCys; and CysProLeuIleProGlySerThrThrThrSerThrGlyPro CysLysThrCysThrThrProAlaGlnGlyAsnSerMet PheProSerCys; and c) a physiologically tolerable diluent, said vaccine when introduced into a host, being capable of inducing the production of antibodies and the proliferation of thymus-derived cells in the host, said antibodies immunoreacting with said hepatitis B virus, and said vaccine protecting the host from hepatitis B viral infection.
476041
Chisari Frank V.
Milich David R.
Fetherstonhaugh & Co.
Scripps Clinic And Research Foundation
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