C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2280195
Synthetic DNA molecules encoding HIV gag and modifications of HIV gag are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through stimulation of neutralizing antibody and cell-mediated immunity.
La présente invention a trait à des molécules d'ADN synthétiques codant pour le gag HIV et à des modifications du gag HIV. Les codons des molécules synthétiques sont des codons privilégiés de la cellule hôte étudiée. Ces molécules peuvent être utilisés comme vaccin polynucléotide qui assure une immunoprophylaxie effective contre l'infection par le HIV grâce à la stimulation des anticorps neutralisants et à l'immunité à médiation cellulaire.
Davies Mary-Ellen M.
Freed Daniel C.
Liu Margaret A.
Perry Helen C.
Shiver John W. Jr.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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