Synthetic hiv genes

Details Synthetic hiv genes Synthetic hiv genes

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 31/70 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) C12N 15/57 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2245646

Synthetic DNA molecules encoding HIV genes and modifications of HIV genes are provided. The codons of the synthetic molecules use codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through neutralizing antibody and cell-mediated immunity.

La présente invention, qui concerne des molécules synthétiques d'ADN codant pour des gènes du VIH, concerne également des modifications des gènes du VIH. Les codons des molécules synthétiques utilisent les codons que préfère la cellule hôte cible. Du fait de la neutralisation d'anticorps et de l'immunité acquise grâce aux cellules, ces molécules synthétiques peuvent constituer un vaccin polynucléotidique immunoprophylactiquement efficace contre l'infection par le VIH.

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