Synthetic hla binding peptide analogues and uses thereof

Details Synthetic hla binding peptide analogues and uses thereof Synthetic hla binding peptide analogues and uses thereof

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 39/09 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 7/06 (2006.01) C12N 15/09 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2548135

The present invention provides synthetic peptides comprising at least analogues of a native peptide that specifically bind to HLA A0201 or HLA A0301 molecules on a cell characteristic of a pathophysiologic state, such as a cancer cell, in a mammal. Also provided are pharmaceutical compositions and immunogenic compositions comprising at least the peptide analogue segments or a DNA encoding the same. Also provided are methods of using the synthetic peptides and immunogenic compositions to induce a heteroclitic immune response or to treat a cancer.

La présente invention a trait à des peptides synthétiques comportant au moins des analogues d'un peptide natif de liaison spécifique à des molécules de l'antigène d'histocompatibilité A0201 ou de l'antigène d'histocompatibilité A0301 sur une cellule caractéristique d'un état pathophysiologique, telle qu'une cellule cancéreuse, chez un mammifère. L'invention a également trait à des compositions pharmaceutiques et des composition immunogènes comportant au moins des segments d'analogues peptidiques ou un ADN codant pour de tels segments. L'invention a trait en outre à des procédés d'utilisation des peptides synthétiques et compositions immunogènes pour induire une réponse immunitaire hétéroclite ou pour le traitement d'un cancer.

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