Synthetic human peptides and pharmaceutical compositions...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/00 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2439051

Synthetic peptides of at least 12 and at most 30 amino acid residues comprising a sequence consisting of, or found within, a complementarity- determining region (CDR) found in the heavy or light chain of the human anti- DNA 16/6Id monoclonal antibody, or a sequence obtained by replacement and/or deletion and/or addition of one or more amino residues to said sequence, and salts, chemical derivatives and polymers of said peptides can be used for immunomodulation of systemic lupus erythematosus-associated responses.

L'invention concerne des peptides synthétiques comprenant au moins 12 et au plus 30 résidus d'acides aminés contenant une séquence composée, ou située à l'intérieur d'une région déterminant la complémentarité (CDR) située dans la chaîne lourde ou dans la chaîne légère de l'anticorps monoclonal humain anti-ADN 16/6Id, ou une séquence obtenue par remplacement et/ou suppression et/ou addition d'un ou de plusieurs résidus d'acides aminés dans ladite séquence. L'invention concerne également des sels, des dérivés chimiques et des polymères de ces peptides. Ces composés peuvent être utilisés pour l'immunomodulation de réponses associées au lupus érythémateux systémique.

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