Synthetic inverso or retro-inverso t-cell epitopes

Details Synthetic inverso or retro-inverso t-cell epitopes Synthetic inverso or retro-inverso t-cell epitopes

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 39/00 (2006.01) C07K 7/08 (2006.01) C07K 14/02 (2006.01) C07K 14/11 (2006.01) C07K 14/12 (2006.01) C07K 14/135 (2006.01) C07K 14/145 (2006.01) C07K 14/165 (2006.01) C07K 14/235 (2006.01) C07K 14/34 (2006.01) C07K 14/445 (2006.01) C07K 14/77 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2183977

Synthetic T cell epitope analogues of native T cell epitopes which are partially or completely inverso or retro-inverso modified with respect to the native T cell epitope are shown to be effective as T cell epitopes. These T cell epitope analogues stimulate immune responsiveness when used in place of their native T cell epitope counterparts in vaccines. The invention further relates to the use of these T cell epitope analogues, to vaccines comprising the T cell epitope analogues, to methods of preparing vaccines comprising these T cell epitope analogues, and to antibodies generated using these T cell epitope analogues.

Il a été démontré que des analogues synthétiques d'épitopes de lymphocytes T natifs, qui ont subi une modification inverse ou rétro-inverse partielle ou entière par rapport aux épitopes natifs, présentent une efficacité équivalente à celle de ces derniers. Ces analogues stimulent la réponse immune lorsqu'ils sont utilisés à la place de leurs équivalents natifs dans des vaccins. L'invention se rapporte en outre à l'utilisation de ces analogues, à des vaccins comprenant lesdits analogues, à des procédés de préparation de vaccins les contenant, ainsi qu'à des anticorps générés au moyen desdits analogues d'épitopes de lymphocytes T.

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